Figure 14 | Laboratory Investigation

Figure 14

From: Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns

Figure 14

Schematic representation of AL-LC trafficking in HMCs. The schematic representation illustrates the intracellular trafficking of AL-LCs, as demonstrated with the dynamic (real-time) studies. As shown, there are a number of potential interventions along the way that may prevent AL-LCs from reaching the mature lysosomal compartment where amyloidogenesis normally occurs.

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