Figure 6
From: Antiapoptotic action of hypoxia-inducible factor-1α in human endothelial cells
Group comparisons of HIF-1α in situ hybridization analyses illustrating the effects of normoxia and A/R on cultured HUVECs. Transfection with HIF-1α siRNA significantly decreased the amount of HIF-1α mRNA detectable in HUVECs subjected to anoxic stress. Results in each category represent mean±s.e.m. of three experiments. (A) Normoxic cultures. (B) Cultures transfected with HIF-1α siRNA duplexes and subjected to A/R. (C) Nontransfected cultures subjected to A/R. *Significantly different (P<0.05) compared with the other two groups.
