Figure 7
From: Human heparanase nuclear localization and enzymatic activity
Nuclear localization of heparanase in human oral squamous cell carcinoma. Paraffin-embedded tissue sections from human oral SCC were subjected to immunostaining with anti-heparanase antibodies (pAb 733), as described in ‘ Materials and methods’. (a) Intense, nuclear granular staining of heparanase is seen in most salivary gland tumor cells, with only scant cytoplasmic staining. (b) Nuclear staining of heparanase in the mucosal epithelial tumor cells. Nuclear staining is not detected in the adjacent stromal cells (arrows). Mayer's hematoxylin was used for counterstaining of the cell nuclei (Blue). Images were taken at an original objective magnification of X60.
