Figure 2 | Laboratory Investigation

Figure 2

From: Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat

Figure 2

Ultrastructure (a, b) and TUNEL staining (c) of glomeruli on day 1 of glomerulonephritis. (a) A representative glomerulus of the control animal. Mesangiolysis and fusion of tufts (*) by rupture of endothelial cells (En) are shown. The arrowhead shows an apoptotic cell. (b) A representative glomerulus of the VEGF/VPF-treated animals. Although mesangiolysis (M) is evident, endothelial cells (En) are not ruptured. Bars represent 2 μm. (c) Double staining of the tissue of control glomerulonephritis. Endothelial cells are stained by anti-RECA-1 antibody (red) and an apoptotic cell, shown by the arrow, is stained by TUNEL (black). No apoptotic endothelial cells are found in the glomeruli (magnification × 100).

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