Table 2 Ratios of Tcf/Lef-transcribed genes

From: Tumor-associated E-cadherin mutations do not induce Wnt target gene expression, but affect E-cadherin repressors

Number

Gene symbol

RefSeq

D8

D370A

D9

MDA

   

Fold change

Standard deviation

Fold change

Standard deviation

Fold change

Standard deviation

Fold change

Standard deviation

1

AXIN2

NM_004655

0.99

0.08

0.97

0.79

0.98

0.34

1.04

0.11

2

BMP4

NM_001202

1.42

0.46

1.15

0.47

1.16

0.71

1.07

0.19

3

CCND1

NM_053056

1.08

0.15

1.13

0.54

1.14

0.34

1.01

0.10

4

CD44

NM_000610

1.53

0.66

1.02

0.30

0.91

0.19

1.32

0.69

5

FZD7

NM_003507

0.66

0.39

0.90

0.30

0.86

0.34

0.79

0.28

6

JUN

NM_002228

0.97

0.13

1.07

0.37

1.09

0.23

0.99

0.08

7

LEF1

NM_016269

1.06

0.22

1.00

0.18

1.04

0.83

1.05

0.16

8

MMP7

NM_002423

1.01

0.17

0.95

0.70

0.91

0.33

1.06

0.26

9

MYC

NM_002467

1.40

0.26

0.88

0.43

1.21

0.48

0.95

0.13

10

PLAUR

NM_002659

0.93

0.34

1.06

0.84

1.07

0.43

1.01

0.08

11

PPARD

NM_006238

1.03

0.11

0.89

0.25

1.06

0.42

0.96

0.15

12

TCF1

NM_000545

1.02

0.12

1.00

0.28

0.96

0.37

0.98

0.29

13

VEGF

NM_003376

1.09

0.39

0.91

0.59

0.83

0.49

1.07

0.27

  1. cDNA microarray data (ratios) of Tcf/Lef-transcribed genes for D8, D370A, D9 and MDA. Except of BMP4, MYC, CD44 and FZD7 by D8 cells none of the 13 Tcf/Lef-transcribed genes showed an up- or downregulation compared to WT-transfected MDAs. Amount of 50 μg total RNA were used for cDNA microarray analysis.
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