Figure 12
From: Epithelium–mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage
Schematic representation of the DXR-induced dystrophic catagen stage. T1 (1 day after the first DXR injection): in the matrix, about 2% of the cells were in mitosis. T5 (1 day after the last DXR injection): first significant signs of suffering in the epidermis. About 19% of keratinocytes are oncotic. Apoptosis, occasionally detected in the matrix compartment, is more represented in the CTS. T7 (3 days after the last DXR injection): number of oncotic cells increase both in the epidermis and in the ORS. T10 (6 days after the last DXR injection): the HF appears to have completed is dystrophic catagen pathway and alopecia subsequently arises.
