Figure 5
From: Epithelium–mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage
Electron microscopy of the epidermis from treated rats at T1 (a), T5 (b), T7 (c) and T10 (d). Inset: mitochondria, higher magnification. Note the increase in cristae damage with respect to time, and the progressive swelling and loss of convolute edges and chromatin rarefaction. Bar: 2 μm. (e) Higher magnification of the mitochondria at T1. Note the correct organization of membranes. Bar: 500 nm. (f) higher magnification of the mitochondria at T5. Note the loss of cristae organization, but the maintenance of the external double membrane, indicating that changes in membranes are not imputable to artifacts occurred during sample processing. N: nucleus. Bar: 500 nm.
