Figure 4 | Laboratory Investigation

Figure 4

From: Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin

Figure 4

Immunostaining of MTAP in colon adenoma and carcinoma. (a) Colon adenoma with low-grade dysplasia. Only moderate cytoplasmatic staining was detectable (arrows, × 200). (b) Colon adenoma with high-grade dysplasia. Strong cytoplasmatic staining was found (arrow, × 200). (c) and (d) Colon carcinoma with residual colon adenoma and normal colon epithelium at the margins. (c) A graduation from no staining of the normal colon epithelium (normal) to strong staining of the colon adenoma (adenoma) (high-grade dysplasia) (× 50) and (d) in the colon carcinoma (black arrows, (carcinoma)) with normal colon epithelium left half of the figure (normal). (× 100).

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