Figure 2

Necroinflammatory changes in BALB/c-TGF-β1^−/− livers (H&E-stained sections). (a) Normal histology in BALB/c-TGF-β1^+/+ liver; (b) BALB/c-TGF-β1^−/− livers show extensive necroinflammatory liver disease, primarily in a subcapsular distribution; (c) similar findings are also observed in deeper hepatic parenchyma from BALB/c-TGF-β1^−/− mice; (d) high-power examination of the inflammatory infiltrate seen in necrotic areas from BALB/c-TGF-β1^−/− mice shows a predominance of neutrophils admixed with histiocytes and lymphocytes. Notably, no plasma cells are seen; (e) portal triads in BALB/c-TGF-β1^−/− livers show a lack of inflammation, interface hepatitis, and fibrosis.