Figure 3

Liver histopathology in 129/CF-1 and BALB-background TGF-β1^−/− livers (H&E-stained sections). (a) 129/CF-1-TGF-β1^−/− livers show no necroinflammatory liver disease; (b) BALB.B-TGF-β1^−/− and (c) BALB.K-TGF-β1^−/− livers exhibit necroinflammatory liver disease similar to that observed in BALB/c-TGF-β1^−/− livers; (d) F1(BALB/c × 129/CF-1)-TGF-β1^−/− livers show no necroinflammatory liver disease, indicating that the necroinflammatory liver disease phenotype is recessively inherited.