Table 7 Correlation of the expression of A antigen in the tumor, dysplasia and normal urothelium specimens with the genetic and epigenetic changes in the primary tumor

From: Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene

Case

Genotype

Tumor

Dysplasia expression

Urothelium expression

  

Expression

LOH

Methylation status

  

A-22

A/O1

Positive

O1

M

Positive

Positive

A-1

A/O2

Positive

O2

UM

Positive

Positive

A-10

A/O2

Positive

O2

UM

Positive

Positive

A-3

A/O2

Positive

O2

UM

Positive

Positive

A-46

A/O2

Positive

O2

UM

Positive

Positive

A-5

A/O1

Positive

Ret

UM

Positive

Positive

A-43

A/O1

Positive

Ret

UM

Positive

Positive

AB-5

A/B

Positive

Ret

UM

Positive

Positive

A-5

A/O1

Positive

Ret

UM

Positive

Positive

A-18

A/O1

Positive

Ret

NA

Positive

Positive

A-29

A/A

Positive

NI

UM

Positive

Positive

A-47

A/A

Positive

NI

UM

Positive

Positive

A-14

A/A

Positive

NI

NA

Positive

Positive

A-15

A/O2

Negative

A

M

Positive

Positive

A-16

A/O2

Negative

A

M

Positive

Positive

A-48

A/O2

Negative

A

M

Positive

Positive

A-2

A/O2

Negative

A

UM

Positive

Positive

A-31

A/O1

Negative

A

UM

Positive

Positive

A-6

A/O1

Negative

A

NA

Positive

Positive

A-13

A/O1

Negative

O1

M

Positive

Positive

A-9

A/O1

Negative

O1

UM

Hetero

Positive

A-33

A/O2

Negative

O2

NA

Positive

Positive

AB-2

A/B

Negative

B

M

Positive

Positive

  1. UM and M indicate whether the RE 7 sequences were unmethylated and methylated, respectively;
  2. Hetero: heterogenous expression; NA: not applicable.