Figure 3
From: DNA methylation-dependent silencing of CST6 in human breast cancer cell lines
Methylation analysis of the CST6 proximal promoter and exon 1 in breast cancer cell lines and normal mammary epithelial cells that differentially express CST6. A summary of the methylation analysis of the CST6 promoter (23 CpGs) and exon 1 (32 CpGs) is shown. The black arrow indicates the start of transcription between CpGs 23 and 24. Black circles correspond to fully (100%) methylated CpGs, gray circles correspond to CpGs with intermediate methylation, and open circles correspond to unmethylated CpGs. TMI values for the entire promoter/exon 1 region (55 CpGs) are given for each breast cancer cell line. MCF12A, SK-BR-3, and BT-20 cells express CST6, while the remaining cell lines lack CST6 expression.
