Figure 6

Mouse adrenal function evaluation. Plasma (a) adrenocorticotropic hormone (ACTH, pg/ml) and (b) corticosterone (ng/ml) levels were measured before (basal) or one hour after stress (stressed) induced by vigorous cage shaking. (c) Kinetic studies of corticosterone secretion in response to stress stimulation. Plasma corticosterone levels from four WT and four abcd1 KO mice were measured at indicated time points following induced stress. While there were statistically significant differences between basal ACTH levels of WT and abcd1 KO mice, P<0.003, there were no other statistically significant differences between WT and abcd1 KO mice by either the Student's t-tailed t-test or linear regression analysis. n, number of samples measured. s.e. of measurements is indicated by error bars.