Table 1 Left ventricular geometry, function and histology 4 weeks after administering DOX to mice with and without G-CSF (Protocol 2a)

From: Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy

 

DOX (n=9)

DOX+G-CSF (n=8)

P-value

LVDd (mm)

3.5±0.08

3.3±0.11

0.0913 (NS)

LVDs (mm)

2.8±0.10

2.5±0.12

0.0391*

%FS, (%)

20±1.1

25±1.8

0.0332*

LVEDP (mm Hg)

4.5±0.59

2.7±0.48

0.0471*

LVSP (mm Hg)

74±3.7

91±4.3

0.0123*

Heart Rate (bpm)

470±32

528±35

0.2467 (NS)

+dP/dt (mm Hg/s)

5528±335

6520±291

0.0482*

−dP/dt (mm Hg/s)

−5148±526

−7582±295

0.0023*

Myocyte size (μm)

13.4±0.28

14.3±0.26

0.0399*

%Fibrosis

1.15±0.09

0.57±0.08

0.0004*

CD45+ (cells/HPF)

12±1.3

6.6±0.92

0.0073*

  1. *P<0.05.
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