Figure 8 | Laboratory Investigation

Figure 8

From: The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro

Figure 8

A schematic diagram of the role of the curcumin interruption of PDGF and EGF signaling in the induction of gene expression of PPARγ in activated HSC. Curcumin reduces the level of receptor tyrosine phosphorylation and attenuates the activities of the downstream inter-mediators AKT, ERK and JNK, leading to the interruption of the signal transduction pathways of PDGF and EGF. These, together with other actions, collectively relieve the inhibitory effects on gene expression of PPARγ, leading to the inhibition of cell growth by inducing cell arrest and apoptosis.

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