Figure 7 | Laboratory Investigation

Figure 7

From: H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway

Figure 7

(a, left panel) Measurement of PCNA protein expression in purified cholangiocytes from rats that (immediately after BDL) were treated with NaCl or RAMH for 1 week. PCNA protein expression was decreased in cholangiocytes from BDL rats treated with RAMH compared to cholangiocytes from NaCl-treated rats. Data are mean±s.e.m. of five experiments. *P<0.05 vs corresponding value from BDL rats treated with NaCl. (b, right panel) Measurement of the phosphorylation of PKA in cholangiocytes from rats that (immediately after BDL) were treated with NaCl or RAMH for 1 week. Chronic in vivo administration of RAMH to BDL rats induced a decrease in the phosphorylation of PKA (expressed as ratio to total PKA protein expression) in purified cholangiocytes compared to cholangiocytes from BDL rats treated with NaCl. Data are mean±s.e.m. of three experiments. *P<0.05 vs corresponding value from BDL rats treated with NaCl.

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