Figure 1 | Laboratory Investigation

Figure 1

From: Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture

Figure 1

Histopathological findings of the liver of PCK rats. (a) The intrahepatic bile duct shows chronic cholangitis with lymph-follicle-like aggregation, and lymphocytes infiltrate the biliary epithelial layer (arrows). PCK rat at 6 weeks. H&E, × 200. (b) Clusters of PMNs are seen in the lumen of the bile duct surrounded by many PMNs. PCK rat at 6 weeks. H&E, × 200. (c) Gram-positive and -negative bacteria are mixed in the bile duct lumen. PCK rat at 6 weeks. Gram staining, × 400. (d) Intestinal metaplasia containing goblet cells (arrows) are observed in the bile ducts with infiltration of lymphocytes and PMNs. PCK rat at 10 months. H&E, × 200. (e) Mucin in the cytoplasm of goblet cells (arrows) and in the bile duct lumen (asterisk) are positive for PAS staining. PAS, × 200.

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