Figure 4

Immunohistochemistry for TLR2 and TLR4 in the liver of control rats (a and c) and PCK rats (b and d) at 9 months. (a) TLR2 is not expressed in the BECs (arrow) of bile ducts of control rats. (b) TLR2 is expressed in the cytoplasm and on the luminal surface of BECs (arrow) of bile ducts with moderate inflammation in PCK rats. (c) TLR4 is expressed on the luminal surface of BECs of the bile ducts in the control rat (arrow). (d) TLR4 is expressed in the cytoplasm and more intensely on the luminal surface of BECs of the bile ducts with moderate inflammation (arrow) in PCK rats. Counterstained with hematoxylin, × 400.