Table 1 Chronic suppurative cholangitis and intestinal metaplasia in biliary epithelial cells of PCK rats

Age	(n)	Chronic suppurative cholangitis		Intestinal metaplasia
		Chronic inflammation	Suppurative cholangitis
PCK rats
Fetus	40	0	0	0
0–5 weeks	42	0	0	0
6–10 weeks	15	3 (20%)	2 (13%)	1 (7%)
4–7 months	15	10 (67%)^a^,^b	9 (60%)^b^,^c	4 (27%)
9–10 months	30	22 (73%)^a^,^b	22 (73%)^a^,^b	21 (70%)^a^,^b^,^d
12–18 months	9	9 (100%)^a^,^b	9 (100%)^a^,^b^,^e	9 (100%)^a^,^b^,^d
Control rats
Fetus	8	0	0	0
0–5 weeks	8	0	0	0
6–10 weeks	9	0	0	0
4–7 months	5	0	0	0
9–10 months	5	0	0	0
12–18 months	5	0	0	0

PCK, polycystic kidney; PMN, polymorphonuclear leukocytes.
Fetus means rats from 18 to 21 days of gestation; suppurative cholangitis was regarded as cholangitis with infiltration of PMNs in biliary lumen.
^aP<0.01 compared with control rats at each age.
^bP<0.01 compared with 6–10 weeks in PCK rats.
^cP<0.05 compared with control rats at each age.
^dP<0.01 compared with 4–7 months in PCK rats.
^eP<0.05 compared with 4–7 months in PCK rats.

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