Figure 4
From: Activin receptor-like kinase 1 is essential for placental vascular development in mice
Comparison of Alk1 and Flk1 expression patterns in the definitive placentae. Whole-mount X-gal-stained placentae of E15.5 Alk1+/lacZ (a–c), Tg(Alk1-lacZ) (d–f), and Flk1+/lacZ (g–i) embryos were cleared with organic solvents. Higher magnification of longitudinal view of (a, d, g) is presented in (b, e, h). (c, f, i) Horizontal view of X-gal-stained placenta from fetus side. Note that Alk1 expression is limited to the Lab layer and strong in fetal arteries projecting into the Lab layer. Ar, fetal arteries; Dec, decidua basalis; Emb, embryonic side; Lab, labyrinth layer; Sp, spongiotrophoblast layer; Ut, uterine wall; Ve, fetal veins.
