Figure 4
Liver regeneration after PH. (a) Immunohistochemical staining of BrdU (red) in liver sections at 40 h after PH. Nuclei were counter stained with DAPI (blue). Original magnification: × 40. (b) Summary of Brdu-positive cells after PH. BrdU-labeled hepatocytes were counted 24, 40, 48 and 72 h after PH. For each group (L-Stat3−/− and Stat3f/+ mice) 4–6 mice were used for each time point. *P<0.05 between L-Stat3−/− (closed bar) and Stat3f/+ mice (open bar). (c) Recovery of liver mass after PH. Liver weights were measured at different time points after 70% PH. For each group (L-Stat3−/− and Stat3f/+ mice) 4–6 mice between 10 and 15 weeks old were used for each time point. (d) Histopathological examination of liver sections after PH. HE staining of liver sections from L-Stat3−/− and Stat3f/+ mice was performed at indicated time points after PH. Original magnification: × 20.
