Figure 3 | Laboratory Investigation

Figure 3

From: Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin

Figure 3

Circulating antithrombin in mice treated with bortezomib. (a) Time-dependent effects of bortezomib on the antigen and anti-FXa anticoagulant function levels of antithrombin in plasma. (b) Levels of the latent circulating form of antithrombin as revealed by native PAGE with 6 M urea and immunoblotting (Lat, latent) quantified by optical densitometry of the gels. Results are presented as percentages of their baseline levels as means±s.e.m. of five different experiments (*P<0.05; ***P<0.001).

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