Figure 4 | Laboratory Investigation

Figure 4

From: Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin

Figure 4

Time-dependent histological and ultrastructural effects of bortezomib on mice livers. (a) Haematoxylin and eosin ( × 40 magnification), congo red (CR) (featuring β-amyloid deposit staining) and amylase-PAS (PAS) (featuring glycoprotein accumuli) ( × 100 magnification in both cases) under light microscopy. Additionally, transmission electron microscopy (EM) revealed ultrastructural features of bortezomib-treated hepatocytes from mice ( × 8000 magnification). Black arrows indicate the presence of intracellular Mallory bodies and/or glycoprotein deposits. Red arrows indicate areas of dilated ER cisternae. (b) Digital amplification of confronting cisternae and dilated ER from a mouse treated with bortezomib for 4 days under electron microscopy. Red arrows indicate areas of dilated ER cisternae.

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