Figure 2

Nude mice 8 days after injection of 2.5 × 108 pfu adeno-vpf/vegf into tibialis anterior muscle of the hind limbs (a and b) or 5 days after injection into the left ear (c and d). Note prominent tissue edema and new blood vessel formation. Evans blue dye was injected iv 20 minutes before photographing d; prominent bluing reflects leakage of dye-plasma protein complexes from locally hyperpermeable ear vessels.