Table 4 Lymphoma Incidence and Frequency of Morphologic Types in NFS.Akv2 (4-2K) Populations Segregating for Germline Ecotropic MuLV Sequences

From: Accelerated Appearance of Multiple B Cell Lymphoma Types in NFS/N Mice Congenic for Ecotropic Murine Leukemia Viruses

 

Ecotropic MuLV expression*

 

Positive

Negative

Lymphoma type†

No.

% of lymphomas

Age‡

Fraction clonal§

No.

% of lymphomas

Age

Fraction clonal

Low grade

        

 SLL

8

12

570 ± 106

3/3

3

12

706 ± 19

 

 FL

11

16

570 ± 74

5/5

1

4

658

1/1

 MZL

24

36

526 ± 118

12/12

16

64

612 ± 104

4/4

 Composite¶

3

4

451 ± 97

1/1

0

   

Subtotal

46

69

  

20

80

  

Intermediate grade

        

 MZL+

0

   

2

8

675

 

High grade

        

 MZL++

2

3

553

1/1

2

8

675

 

 IBL

3

4

499 ± 83

1/1

0

   

 CBLdiff

3

4

551 ± 14

2/2

0

   

 LL

10

13

373 ± 198

6/6

1

4

744

1/1

 Composite#

3

4

474 ± 110

2/2

0

   

Subtotal

21

31

  

3

12

  

Total lymphomas/no. of mice

67/83

81

511 ± 132

33/33

25/61

41

640 ± 97

6/6

  1. *Ecotropic virus-positive mice carry the 25 kb germline EcoRI fragment hybridizing in Southern blotting with the EcoSp probe and associated with spontaneous and/or induced expression of infectious ecotropic MuLV. Mice in the virus-negative group carry EcoRI EcoSp-reactive fragments of 22 kb, 15.3 kb, or no reactive sequences.
  2. †Abbreviations and definitions as for Table 1. Composite tumors are defined as two distinct lymphoma types occurring in the same spleen.
  3. ‡Age at diagnosis in days ± standard deviation.
  4. §Fraction clonal = no. of cases with monoclonal or oligoclonal IgH or TCRβ rearrangements divided by no. tested.
  5. ¶Includes FL/MZL (3 cases).
  6. #Includes CBL/MZL (2), IBL/SLL (1).
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