Figure 1 | Laboratory Investigation

Figure 1

From: HMGI-C and HMGI(Y) Immunoreactivity Correlates with Cytogenetic Abnormalities in Lipomas, Pulmonary Chondroid Hamartomas, Endometrial Polyps, and Uterine Leiomyomas and is Compatible with Rearrangement of the HMGI-C and HMGI(Y) Genes

Figure 1

a, Nuclear reactivity for HMGI-C in the neoplastic adipocytes of a lipoma (case 17L); t(2;12)(q35;q15) was identified in the tumor karyotype, FISH analysis was not performed. b, The corresponding immunohistochemical stain for HMGI(Y) is negative (case 17L). c, Positive nuclear reactivity for HMGI(Y) in the mesenchymal cells of a pulmonary chondroid hamartoma (case 11P); t(6;10)(p21.3;q22.3) was identified in the tumor karyotype (Fig. 2d), FISH analysis results are illustrated in Figure 2c and are compatible with HMGI(Y) gene rearrangement. d, The corresponding immunohistochemical stain for HMGI(Y) is negative (case 11P). e, Nuclear reactivity for HMGI(Y) in the neoplastic smooth muscle cells of an uterine leiomyoma (case 1M); t(6;14)(p21;q24) was identified in the tumor karyotype; FISH analysis results are compatible with HMGI(Y) gene rearrangement. f, The corresponding immunohistochemical stain for HMGI-C is negative (case 1M). g, Nuclear reactivity for HMGI-C in the stromal component of an endometrial polyp (case 10E); t(12;14)(q15;q24–25) was identified in the tumor karyotype; FISH analysis results are compatible with HMGI-C gene rearrangement. The corresponding immunohistochemical stain for HMGI(Y) is negative (case 10E).

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