Figure 8 | Laboratory Investigation

Figure 8

From: CD4+ T Cell-Mediated Cytotoxicity Toward Thyrocytes: The Importance of Fas/Fas Ligand Interaction Inducing Apoptosis of Thyrocytes and the Inhibitory Effect of Thyroid-Stimulating Hormone

Figure 8

Inhibitory effects of TSH on CD4+ T cell-mediated cytotoxicity toward IFN-γ-stimulated thyrocytes. Thyrocytes from patients with Graves’ disease were incubated with rIFN-γ (500 IU/ml) for 72 hours in the presence or absence of 10 mIU/ml of TSH. After cultivation, the cells were labeled with 51Cr, and further incubated with CD4+ T cells (E/T ratio of 10) for 18 hours in the presence of 1 μg/ml of SEB. Results shown are the mean±SD of five experiments. *; p < 0.01, compared with data in the absence of TSH.

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