Table 1 Changes in Cu Concentrations in the Heart and Liver of MT-TG (MT+) and Non–TG (MT−) Mice

From: Metallothionein Inhibits Myocardial Apoptosis in Copper-Deficient Mice: Role of Atrial Natriuretic Peptide

 

Heart (μg/g dry wt)

Liver (μg/g dry wt)

 

wk 3

wk 4

wk 5

wk 3

wk 4

wk 5

CuA/MT−

21.8 ± 2.1

23.8 ± 0.6

25.1 ± 2.7

39.2 ± 8.2

38.7 ± 3.1

37.8 ± 1.4

CuA/MT+

36.8 ± 1.6*

35.5 ± 1.9*

35.7 ± 0.8*

38.9 ± 9.9

36.9 ± 1.2

39.6 ± 5.4

CuD/MT−

15.7 ± 0.8*

9.7 ± 1.3*

7.1 ± 3.3*

10.5 ± 2.5*

5.6 ± 0.4*

5.6 ± 1.3*

CuD/MT+

15.8 ± 4.7*

8.4 ± 0.7*

5.1 ± 0.5*

10.1 ± 0.8*

5.6 ± 0.6*

5.1 ± 1.7*

  1. Values are means ± sd (n = 6), CuA, copper-adequate; CuD, copper deficient.
  2. *Significantly different from the CuA non-TG (CuA/MT−) mice (p < 0.05) and significantly different from week 3 (p < 0.05).
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