Table 3 Number of Spirochetesa in Tissues from Infected Immunosuppressed (B1–4) and Uninfected (C1) M. Mulatta

From: Localization of Borrelia Burgdorferi in the Nervous System and Other Organs in a Nonhuman Primate Model of Lyme Disease

Tissuesb

B1

B2

B3

B4

C1

Cervical cord

 Parenchyma

 

0.0b

   

 Roots

 

0.05 (0.2) b

   

 Leptomeninges

 

0.1 (0.3) b

   

Thoracic cord

 Parenchyma

0.0a

0.0a

0.0a

0.0a

0.0a

 

0.0b

0.0b

  

0.0b

 Roots

 

0.30 (0.7) a

 

0.25 (0.5) a

0.0 a

 

0.0b

0.20 (0.4) b

   

 Leptomeninges

 

0.13 (0.5) a

 

0.0a

0.0a

 

0.0b

0.30 (0.5) b

   

Lumbar cord

 Parenchyma

0.0b

0.0b

 

0.0b

0.0b

 Roots

0.0b

1.50 (2.8) b

0.36 (0.5) b

1.0 (1.9) b

0.0b

 Leptomeninges

0.0b

0.15 (0.4) b

 

0.3 (0.5) b

0.0b

Peripheral nerve

 Perineurium

   

0.0a

0.0a

 

3.3 (2.6) b

6.1 (8.9) b

  

0.0b

 Endoneurium

 

0.3 (1.1) a

 

0.0a

0.0a

 

0.2 (0.6) b

0.0b

   

 Skeletal muscle

0.05 (0.2) a

 

0.23 (0.6) a

 

0.0a

  

0.8 (1.1) b

0.80 (1.4) b

0.1 (0.32) b

 
   

11 (10) c

15 (17) c

 

Bladder

 Mucosa

  

8.3 (7.6) a

7.2 (10.7) a

0.0a

 Muscle

  

32 (36) a

7.2 (8.7) a

0.0a

 Heart

 

1.1 (1.2) a

1.0 (1.7) a

0.6 (0.80) a

0.0a

    

1.0 (2.16) b

0.0b

 Aorta (adventicia)

 

0.2 (0.4) b

   
  1. aTwenty consecutive 200 × microscopic fields stained with anti-B. burgdorferi polyclonal antibody were counted by a masked examiner; results are given as mean (SD) number of spirochetes/200 × field.
  2. bThe tissues were (a) fixed in formalin and embedded in paraffin, (b) fixed in paraformaldehyde and frozen, and (c) frozen unfixed.
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