Figure 3 | Laboratory Investigation

Figure 3

From: Analysis of the IGF Axis in Preneoplastic Hepatic Foci and Hepatocellular Neoplasms Developing after Low-Number Pancreatic Islet Transplantation into the Livers of Streptozotocin Diabetic Rats

Figure 3

Immunohistochemical localization of insulin (B), IGF-I (C), IGFBP-4 (D), IGF-I receptor (IGF-IR) (E), and IGF-II/mannose 6-phosphate receptor (IGF-II/M6PR) (F) in a GSF 4 months after islet transplantation. Polyclonal antisera directed against insulin, IGF-I, IGFBP-4, the β subunit of IGF-IR, and IGF-II/M6PR were used as primary antibodies. The periodic acid Schiff (PAS) reaction shows an increase of glycogen content in GSF (A). In B, insulin-producing islet cells are indicated by an arrow. IGF-I, IGFBP-4, and IGF-II/M6PR expressions are increased in the GSF, and IGF-IR expression is unchanged compared with the surrounding liver tissue. Parallel sections are depicted in A to F. Original magnification, ×70.

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