Figure 4 | Laboratory Investigation

Figure 4

From: Analysis of the IGF Axis in Preneoplastic Hepatic Foci and Hepatocellular Neoplasms Developing after Low-Number Pancreatic Islet Transplantation into the Livers of Streptozotocin Diabetic Rats

Figure 4

Immunohistochemical localization of IGF-I (B), IGFBP-4 (C), IGF-IR (D), and IGF-II/M6PR (E) in a small hepatocellular adenoma (HCA) 18 months after islet transplantation. The PAS reaction shows that only a part of the adenoma contains glycogen-storing hepatocytes and that some tumor cells are PAS-negative (A). Similar to GSF, shown in Figure 3, expressions of IGF-I, IGFBP-4, and IGF-II/M6PR are increased. IGF-IR is also increased in the HCA compared with the nontumorous liver tissue and the GSF. Parallel sections are depicted in A to E. Original magnification, ×25.

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