Figure 6 | Laboratory Investigation

Figure 6

From: Analysis of the IGF Axis in Preneoplastic Hepatic Foci and Hepatocellular Neoplasms Developing after Low-Number Pancreatic Islet Transplantation into the Livers of Streptozotocin Diabetic Rats

Figure 6

ISH with [35S]-labeled antisense RNA probes in parallel sections of a HCC (left part of the figures), 24 months after islet transplantation. A strong increase of IGF-II (B) and decreases of IGF-I (A) and IGFBP-1 (D) mRNA expression compared with the neighboring nontumorous liver tissue (right part of the images) is seen. IGFBP-1 (C) mRNA was present at approximately the same levels in tumorous and nontumorous liver tissue. Dark field illumination. Original magnification, ×40.

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