Table 1 Androgen Receptor Expression and Gene Alterations in Extramammary Paget's Disease

Case No.	Age/sex	Tumor^a	Immunohistochemistry^b			RT-PCR^c	FISH^c	Sequencing^c
			% of tumor cells stained	Intensity of staining	AR score
1	86/F	in situ	2	2	4	NE	NE	NE
2	80/M	in situ	1	1	2	NE	NE	NE
3	72/M	in situ	1	1	2	NE	NE	NE
4	70/F	in situ	3	2	5	NE	NE	NE
5	72/F	in situ	1	2	3	NE	NE	NE
6	71/M	in situ	3	2	5	NE	NE	NE
7	72/M	in situ	2	3	5	NE	NCN	NE
8	5/F	in situ	3	2	5	NE	NE	NE
9	75/M	in situ	4	1	5	NE	NE	NE
10	71/M	in situ	0	0	0	NE	NE	NE
11	52/F	in situ	3	3	6	NE	NCN	NE
12	68/M	in situ	0	0	0	NE	NE	NE
13	70/M	in situ	2	2	4	NE	NE	NE
14	63/M	in situ	3	3	6	NE	NCN	NE
15	67/F	in situ	1	1	2	NE	NE	NE
16	76/F	in situ	1	1	2	NE	NE	NE
17	77/F	in situ, R	4	3	7	NE	NCN	NE
18	48/M	Invasive	2	2	4	NE	NE	NE
19	78/M	Invasive	2	2	4	NE	NCN	NE
20	84/M	Invasive	1	1	2	NE	NE	NE
21	70/M	Invasive	1	2	3	NE	NCN	NE
22	76/M	Invasive	0	0	0	NE	NE	wild-type
23	78/M	Invasive	0	0	0	NE	NCN	wild-type
24	58/M	Invasive	1	1	2	NE	NCN	wild-type
25	63/M	Invasive	0	0	0	NE	NE	NE
		LN meta	0	0	0	NE	NE	NE
26	76/M	Invasive	1	2	3	NE	NA	wild-type
		LN meta	1	1	2	+	NA	wild-type
27	64/M	Invasive	4	1	5	NE	NCN	NE
		LN meta	4	3	7	+	NCN	wild-type
28	72/M	Invasive	0	0	0	NE	NCN	wild-type
		LN meta	0	0	0	−	NA	NE
29	78/M	Invasive	4	3	7	NE	NE	NE
		LN meta	4	3	7	+	NCN	wild-type
30	72/M	Invasive	4	3	7	NE	NCN	wild-type
		LN meta	4	3	7	+	NA	wild-type

^ain situ, in situ primary tumor; in situ, R, recurrent in situ tumor; Invasive, invasive primary tumor; LN meta, lymph node metastasis.
^bAR score is a sum of percentage of tumor cells stained (0, no staining; 1, less than 25%; 2, 26%–50%; 3, 51%–75%; 4, 76%–100%) and the staining intensity (0, absent; 1, weak; 2, moderate; 3, strong).
^cNE, not examined; NCN, normal copy number; NA, not applicable.

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