Figure 3
From: VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
Effects of immunoneutralization of ICAM-1, VCAM-1, and MAdCAM-1 on A, flux of rolling leukocytes and B, leukocyte adhesion. Immunoneutralization of either ICAM-1, VCAM-1, or MAdCAM-1 had no effect on leukocyte rolling. Blocking of VCAM-1 or MAdCAM-1 abrogated leukocyte adhesion in colonic venules of colitic mice, whereas ICAM-1 blockade did not have any effect. Control MAb UPC-10 had no effect. *p < 0.02 vs control; #p < 0.02 vs colitis without treatment.
