Figure 4
From: VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
Effect of treatment with anti-CAM MAbs or a nonbinding MAb (UPC-10) on A, body weight loss and B, DAI. Treatment with MK1.91 significantly attenuated the loss in body weight from Days 7 to 10 after induction of colitis, induced a more rapid recovery, and resulted in a lower DAI. ♦, YN1/1.7.4 (anti-ICAM-1 MAb); •, MK1.91 (anti-VCAM-1 MAb); [square with a lot of small dots in it], MECA-367 (anti-MAdCAM-1 MAb); ◬, UPC-10 (control MAb). *p < 0.05 vs UPC-10 treated colitic mice.
