Table 1 Clinical, Macroscopic, Histological, and Biochemical Changes in Control and DSS-Treated Mice
From: VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
Group | Δ Body weight (g) | Stool consistency | Rectal bleeding | DAI | Colon weight (mg) | Colon length (mm) | Colon weight/length (mg/mm) | Microscopic score | MPO activity (U/g tissue) |
---|---|---|---|---|---|---|---|---|---|
Control | 0.2 ± 0.2 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 297.3 ± 7.7 | 95.6 ± 1.4 | 3.1 ± 0 | 0 ± 0 | 0.4 ± 0.07 |
DSS | −2.2 ± 0.3a | 1.0 ± 0.1b | 1.3 ± 0b | 1.7 ± 0.1b | 340 ± 11.8a | 73.7 ± 1.7b | 4.6 ± 0.1b | 52.1 ± 6.7b | 1.9 ± 0.3a |