Table 1 Clinical, Macroscopic, Histological, and Biochemical Changes in Control and DSS-Treated Mice

From: VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice

Group

Δ Body weight (g)

Stool consistency

Rectal bleeding

DAI

Colon weight (mg)

Colon length (mm)

Colon weight/length (mg/mm)

Microscopic score

MPO activity (U/g tissue)

Control

0.2 ± 0.2

0 ± 0

0 ± 0

0 ± 0

297.3 ± 7.7

95.6 ± 1.4

3.1 ± 0

0 ± 0

0.4 ± 0.07

DSS

−2.2 ± 0.3a

1.0 ± 0.1b

1.3 ± 0b

1.7 ± 0.1b

340 ± 11.8a

73.7 ± 1.7b

4.6 ± 0.1b

52.1 ± 6.7b

1.9 ± 0.3a

  1. ap < 0.05 vs control.
  2. bp < 0.0001 vs control.