Table 4 Leukocyte-Endothelial Cell Interactions at Day 5 after Colitis Induction
From: VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
DSS-induced colitis + MAb anti- | ||||||
|---|---|---|---|---|---|---|
Group | Control | Colitis without treatment | UPC-10 (nonbinding) | ICAM-1 | VCAM-1 | MAdCAM-1 |
Flux of rolling leukocytes/min | 27.1 ± 3.1 | 59.0 ± 9.4a | 55.4 ± 11.7a | 61.2 ± 14.1a | 30.8 ± 5.9b | 51.6 ± 4.2a |
Adherent leukocytes/100 μm | 0.8 ± 0.1 | 5.8 ± 0.4a | 5.5 ± 1.1a | 4.6 ± 2.2a | 3.1 ± 0.6a,b | 3.6 ± 0.6a |
