Figure 2

Intra-individual correlation between telomere length in PBMC and skin fibroblasts. A, Telomere Southern blots from four individuals of similar age. Telomeres are either from PBMC (B) or from skin fibroblasts (F) at a population doubling level between 10 and 15 after explantation. For three patients, two parallel fibroblast experiments each are shown to indicate the amount of variation. Size markers (in kbp) are indicated. B, Telomere length residuals (difference to average length) from 24 individuals. Data are from control individuals (open circles), patients with primary dementia (open triangles), patients with stroke and related risk factors (grey circles), and patients with probable vascular dementia (black circles). Data are averages of between three and seven independent measurements with standard errors of 50 to 350 bp.