Table 1 Correlation of ApoE and GST Genotypes with Vascular Dementiaa

From: Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

 

APOE

GSTT1

GSTM1

GSTP1

TELO

 

ɛ2, ɛ3

ɛ4

wt

null

wt

null

wt

mut

long

average

short

CONT

11

8

17

2

8

11

8

11

7

7

5

STR

14

3

11

4

7

8

10

5

3

9

5

AD

9

4

13

0

6

7

2

11

3

4

6

VaD

19

7

21

5

15

11

12

14

0

8

18

p (Chisq)

0.440

0.209

0.748

0.057

0.013

  1. APOE, apolipoprotein E; GST, glutathione-S-transferase; TELO, telomere length distribution; CONT, controls; STR, patients with stroke-related diseases; AD, Alzheimer's dementia; VaD, vascular dementia; Chisq, Chisquare test.
  2. aApoE and GST genotypes do not correlate to vascular dementia. A random subgroup of 75 patients (73 for GST) was analyzed for polymorphisms in the ApoE, GSTT1, GSTM1, and GSTP1 genes. Diagnostic groups are abbreviated as in Figure 3. Numbers of patients per group are given, and the error probabilities according to a Chisquare test are indicated. For comparison, the telomere length distribution (TELO) in these 75 patients is included.
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