Figure 1 | Laboratory Investigation

Figure 1

From: Cell Lineage Analysis during Liver Development Using the spfash-Heterozygous Mouse

Figure 1

Mosaic analysis for bile duct differentiation. If periportal progenitors for biliary epithelial cells grow more extensively than hepatoblasts in other regions in the mosaic liver, in which hepatoblasts of two genotypes for ornithine transcarbamylase (OTC) are mixed, the OTC mosaicism in bile duct cells would be biased toward either OTC-positive or -negative patches (arrows). Periportal mosaicism would also become different from that in other hepatic regions. Periportal connective tissue is not drawn. HC, hemopoietic cells; OTC+, OTC-positive hepatoblasts; OTC−, OTC-negative hepatoblasts; PV, portal vein.

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