Figure 1 | Laboratory Investigation

Figure 1

From: Ulcerative Proctitis, Rectal Prolapse, and Intestinal Pseudo-Obstruction in Transgenic Mice Overexpressing Hepatocyte Growth Factor/Scatter Factor

Figure 1

Analysis of transgenic hepatocyte growth factor/scatter factor (HGF/SF), native c-met, c-kit, and interleukin-2 (IL-2) transcripts in transgenic mouse colons by Northern blot hybridization. A, HGF/SF transgene expression in distal colons from 4- to 8-week-old MH19 and MH37 transgenic mice with (+) or without (−) the addition of 25 mm zinc sulfate in the drinking water. B, Endogenous c-met, c-kit, and IL-2 expression in distal colons, including rectums, from 12-week-old control (−) and MH19 transgenic (+) female mice. Note significantly reduced expression of IL-2 in transgenic distal colon. Filters were rehybridized with a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) probe to assess RNA loading and transfer variation.

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