Figure 4 | Laboratory Investigation

Figure 4

From: Ulcerative Proctitis, Rectal Prolapse, and Intestinal Pseudo-Obstruction in Transgenic Mice Overexpressing Hepatocyte Growth Factor/Scatter Factor

Figure 4

Lack of neuromuscular pathology in intestinal tracts of HGF/SF transgenic mice. A, X-gal-stained terminal colons of a HGF/SF, DβH-nlacZ double-transgenic mouse (top), and its DβH-nlacZ single-transgenic littermate (bottom) show similar uniform distributions of ganglion cell nuclei. B and C, Acetylcholinesterase-stained whole-mount preparations of mid-large intestine from a HGF/SF transgenic mouse (C) and its littermate (B) illustrate the normal two-dimensional architecture of the myenteric plexus that was associated with both genotypes. D and E, Photomicrographs of hematoxylin-and-eosin stained longitudinal sections of mid-large intestine from a symptomatic HGF/SF transgenic mouse (E) and its littermate (D) show nearly identical features. The only differences between the two are attributable to differences in tissue shrinkage, partially related to segment distension at the time of fixation. Scale bars: A, 800 μm; B and C, 100 μm; D and E, 50 μm.

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