Figure 1 | Laboratory Investigation

Figure 1

From: Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris

Figure 1

Immunohistochemical detection of various chemokines and receptors in psoriatic lesions and nonlesional skin. Typical microscopic appearance of a psoriatic lesion characterized by parakeratotic hyperkeratosis and profound perivascular mononuclear cell (MNC) infiltrate (A), and normal microscopic appearance of nonlesional skin (B) (A and B, hematoxylin counterstain; magnification, × 200). There are a significant number of CXCR3+ lymphocytes in the perivascular space and the basal layer of the epidermis in lesional skin (C), whereas rare CXCR3+ cells are present in nonlesional skin (D). Within lesional skin, many of the perivascular MNCs also express CCR4 (E), but CCR4+ cells are rare in nonlesional skin (F). In lesional skin, IP-10 and monokine induced by interferon-γ (MIG) were expressed by dermal blood vessels, infiltrating MNCs (G and I), and there was light immunoreactivity in the epidermis in many cases. In nonlesional skin, there was minimal IP-10 and MIG immunoreactivity (H and J). (C to J: immunoperoxidase technique; hematoxylin counterstain; magnification, × 400).

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