Figure 7 | Laboratory Investigation

Figure 7

From: Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris

Figure 7

Model of lymphocyte homing to the skin. CLA + lymphocytes bind to E-selectin expressed on the dermal endothelium within psoriatic lesions. The CXCR3+CCR4+ lymphocytes then are exposed to the chemokines IP-10, MIG, and TARC expressed by the endothelium. This activates the cells and causes them to bind firmly to the endothelium through the LFA-1/ICAM-1 and/or VLA-4/VCAM-1 interaction. CXCR3+CCR4+ lymphocytes then follow the IP-10, MIG, and/or MDC gradients to the dermis. Next, CXCR3+ lymphocytes follow the IP-10/MIG gradient to the epidermis, and during their migration, the cells up-regulate αEβ7 and bind avidly to E-cadherin expressed by keratinocytes. The cells remain firmly adherent until they are lost with detaching squames.

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