Figure 2 | Laboratory Investigation

Figure 2

From: Augmented Intestinal Trefoil Factor (TFF3) and Loss of pS2 (TFF1) Expression Precedes Metaplastic Differentiation of Gastric Epithelium

Figure 2

Trefoil peptide expression was assessed by RIA at various times in margins of cecal ulcers induced in Wistar rats (n = 6 per group) at laparotomy by topical serosal application of glacial acetic acid to the anterior cecum. Circular mucosal ulcers of area 12 to 25 mm2 were produced by this treatment. Levels of ITF expression in ulcer margins (shaded bars) seemed to rise modestly and remain elevated, but this was not statistically significant compared with tissue from sham-operated animals at day 24 (open bar; p > 0.1, Kruskal-Wallis one-way ANOVA on ranks).

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