Figure 1 | Laboratory Investigation

Figure 1

From: Amplification of Growth Regulatory Genes in Intraductal Breast Cancer Is Associated with Higher Nuclear Grade but Not with the Progression to Invasiveness

Figure 1

Laser microdissection and subsequent quantitative PCR analysis of intraductal carcinoma cells (Case 9). A to D, Dissection and isolation of intraductal tumor cells (methylene blue staining, original magnification, × 100). E and F, Amplification of the c-erbB2 gene in DCIS (E) leads to shifting of the amplification plot (red line) to the left compared with adjacent microdissected normal tissue (F) (intermediate level of amplification: 5.2 ± 0.8). App gene (blue line) serves as internal reference gene.

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