Figure 2 | Laboratory Investigation

Figure 2

From: Amplification of Growth Regulatory Genes in Intraductal Breast Cancer Is Associated with Higher Nuclear Grade but Not with the Progression to Invasiveness

Figure 2

Quantification of c-erbB2 amplification in two specimens of DCIS VN3. A and C, The histologic appearance (hematoxylin and eosin stained, original magnification, × 200); and B and D, the corresponding amplification plots. A and B, Low-level amplification in Case 17 with a small shift of the c-erbB2 amplification plot (red line) of about one PCR cycle to the left compared with adjacent normal tissue. App gene (blue line) serves as an internal reference gene. C and D, High-level amplification in Case 5 with a much greater shifting range of the c-erbB2 amplification plot of about five PCR cycles to the left. App gene (blue line) serves as an internal reference gene.

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