Figure 1 | Laboratory Investigation

Figure 1

From: Human Hepatocellular Carcinoma (HCC) Cells Require Both α3β1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion

Figure 1

Human hepatocellular carcinoma (HCC) cell invasion through a reconstituted basement membrane (BM) (Matrigel). HCC cell invasion tested with a chemoinvasion assay through Matrigel. After 6 hours, Chang, HLE, HLF, and SK-Hep1 invade through the reconstituted BM (Matrigel), whereas Alexander, Hep3B, HepG2, and HepG2.2.15 do not. HT-1080, a well-known highly invasive cell line, was used as a positive control. Invasive cells were quantified with image analysis software. Results are expressed as the mean ± sd of the invasive cells per filter. Each condition is tested at least in quadruplicate; bars represent distinct experiments.

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