Figure 2 | Laboratory Investigation

Figure 2

From: Human Hepatocellular Carcinoma (HCC) Cells Require Both α3β1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion

Figure 2

HCC cell migration on extracellular matrix (ECM) proteins. All HCC cell lines migrate efficiently on transwell filters coated with Ln-1 and Coll IV (10 μg/ml). Chang, HLE, HLF, and SK-Hep-1 had a stronger migration on Ln-5 (1 μg/ml) (filled bar), than on other ECM proteins; whereas Alexander, Hep3B, HepG2, and HepG2.2.15 were not motile on Ln-5. None of the HCC cell lines migrated on blotto-coated filters used as controls. Results are expressed as the mean number of cells in the microscopic field (original magnification, × 400) ± sd.

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