Figure 3 | Laboratory Investigation

Figure 3

From: Human Hepatocellular Carcinoma (HCC) Cells Require Both α3β1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion

Figure 3

HCC cell scattering on Ln-5. HCC cells seem to be in contact with one another, and are arranged as small island-like structures in control wells (a to h). In the presence of Ln-5, HLE (a and a′), HLF (b and b′), SK-Hep1 (c and c′), and Chang (d and d′) show evident scattered activity, the cells are no longer in contact, and are elongated with filopodia and lamellipodia. On the contrary, HepG2 (e and e′), Hep3B (f and f′), Alexander (g and g′), and HepG2.2.15 (h and h′) remain in contact with each other and do not scatter in the presence of Ln-5. Cell morphologies were examined and photographed using a phase-contrast microscope (original magnification, × 200).

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